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Pathway Description

Kanamycin Action Pathway (new)

Homo sapiens

Drug Action Pathway

Kanamycin is an antibiotic from the aminoglycoside family. It is used to treat a variety of infections caused by different bacteria. This drug is administered orally, intravenously, or by an intramuscular injection. Kanamycin is derived from Streptomyces kanamyceticus. It acts by binding irreversibly to the 30S subunit of the ribosome and 16S rRNA as it interferes with protein synthesis and wobble base pairing in tRNA. Specifically, this drug binds four nucleotides of the 16S rRNA and a single amino acid of the S12 protein. Interference in protein synthesis causes misreading leading to non-functional and toxic peptides, leading to the death of the bacteria. Like most aminoglycosides, it is associated with nephrotoxicity and ototoxicity.

References

Kanamycin Pathway (new) References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. doi: 10.1038/nrd2199.

Pubmed: 17139284

Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. doi: 10.1038/nrd2132.

Pubmed: 17016423

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	Kanamycin
	Streptomycin

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