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Pathway Description
Quinupristin Action Pathway
Homo sapiens
Drug Action Pathway
Quinupristin is an antibiotic agent usually used in combination with dalfopristin, to treat Enterococcus faecium bacteremia and skin infections. It inhibits the late phase of protein synthesis by binding to the 50S ribosomal subunit preventing elongation of the forming polypeptide and causing the protein chain to be released prematurely creating a non-functional protein.
References
Quinupristin Pathway References
Allington DR, Rivey MP: Quinupristin/dalfopristin: a therapeutic review. Clin Ther. 2001 Jan;23(1):24-44. doi: 10.1016/s0149-2918(01)80028-x.
Pubmed: 11219478
Lamb HM, Figgitt DP, Faulds D: Quinupristin/dalfopristin: a review of its use in the management of serious gram-positive infections. Drugs. 1999 Dec;58(6):1061-97. doi: 10.2165/00003495-199958060-00008.
Pubmed: 10651391
Manzella JP: Quinupristin-dalfopristin: a new antibiotic for severe gram-positive infections. Am Fam Physician. 2001 Dec 1;64(11):1863-6.
Pubmed: 11764864
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