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Pathway Description
Viomycin Action Pathway
Homo sapiens
Drug Action Pathway
Viomycin is an antibiotic used to treat Mycobacterium tuberculosis and binds to the ribosome displacing structures leading to inhibition of protein synthesis. It binds to the interface between helix 44 of the small ribosomal subunit and helix 69 of the large ribosomal subunit which stops tRNA from binding to the A site and the addition of amino acids to a polypeptide chain.
References
Viomycin Pathway References
Holm M, Borg A, Ehrenberg M, Sanyal S: Molecular mechanism of viomycin inhibition of peptide elongation in bacteria. Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):978-83. doi: 10.1073/pnas.1517541113. Epub 2016 Jan 11.
Pubmed: 26755601
Ly CT, Altuntop ME, Wang Y: Single-molecule study of viomycin's inhibition mechanism on ribosome translocation. Biochemistry. 2010 Nov 16;49(45):9732-8. doi: 10.1021/bi101029g. Epub 2010 Oct 25.
Pubmed: 20886842
Zhang L, Wang YH, Zhang X, Lancaster L, Zhou J, Noller HF: The structural basis for inhibition of ribosomal translocation by viomycin. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10271-10277. doi: 10.1073/pnas.2002888117. Epub 2020 Apr 27.
Pubmed: 32341159
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