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Pathway Description
Sulfamethizole Action Pathway
Escherichia coli (strain K12)
Drug Action Pathway
Sulfamethizole is a synthetic bacteriostatic antibiotic from the sulfonamide drug class. It has a broad spectrum against most gram-positive and many gram-negative organisms. This drug inhibits the replication of the infecting bacteria by competitively binding the dihydropteroate synthase protein. This enzyme catalyzes one of the reactions of the folic acid metabolism acid. With this inhibition, the bacteria can't synthesize folic acid, an essential component for their growth (DNA). The inhibition causes the bacteria not to be able to replicate anymore but does not cause their death. It is administered as an oral capsule.
References
Sulfamethizole Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Watanabe H, Hastings JW: Inhibition of bioluminescence in Photobacterium phosphoreum by sulfamethizole and its stimulation by thymine. Biochim Biophys Acta. 1990 Jun 26;1017(3):229-34. doi: 10.1016/0005-2728(90)90189-b.
Pubmed: 2372557
BARRETT PV, THIER SO: Meningitis and pancreatitis associated with sulfamethizole. N Engl J Med. 1963 Jan 3;268:36-7. doi: 10.1056/NEJM196301032680109.
Pubmed: 13969534
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