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Pathway Description
Sulfacetamide Action Pathway
Escherichia coli (strain K12)
Drug Action Pathway
Sulfacetamide is an anti-infective agent from the sulfonamide drug class (antibiotic). This drug can be used topically to treat skin infections (acne vulgaris), as well as orally to treat urinary tract infections. It is also indicated in the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, and blepharitis. Sulfacetamide is a bacteriostatic drug, it stops the replication of the bacteria. This molecule binds to the dihydropteroate synthase protein in a wide-spectrum activity against most gram-positive and many gram-negative organisms. The inhibited enzyme is essential for the synthesis of folic acid from para-aminobenzoic acid (PABA) molecules. Folic acids are essential for the growth of the bacteria.
References
Sulfacetamide Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Hull CA, Johnson SM: A double-blind comparative study of sodium sulfacetamide lotion 10% versus selenium sulfide lotion 2.5% in the treatment of pityriasis (tinea) versicolor. Cutis. 2004 Jun;73(6):425-9.
Pubmed: 15224788
Del Rosso JQ: Evaluating the role of topical therapies in the management of rosacea: focus on combination sodium sulfacetamide and sulfur formulations. Cutis. 2004 Jan;73(1 Suppl):29-33.
Pubmed: 14959943
Roth HW, Leimbeck R, Sonnenschein B, Anger CB, Weber S: [The effective antibacterial spectrum of sulfacetamide]. Klin Monbl Augenheilkd. 1992 Mar;200(3):182-6. doi: 10.1055/s-2008-1045735.
Pubmed: 1578876
Hevener KE, Zhao W, Ball DM, Babaoglu K, Qi J, White SW, Lee RE: Validation of molecular docking programs for virtual screening against dihydropteroate synthase. J Chem Inf Model. 2009 Feb;49(2):444-60. doi: 10.1021/ci800293n.
Pubmed: 19434845
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