PathWhiz

Pathway Description

Sulfamethazine Action Pathway

Escherichia coli (strain K12)

Drug Action Pathway

Sulfamethazine is an antibacterial agent from the sulfanilamide drug class. It is used as a treatment for various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. Sulfamethazine inhibits the dihydropteroate synthetase enzyme. This protein does the condensation of pteridine and para-aminobenzoic acid (PABA) to produce tetrahydrofolic acid (THF). THF is required for the synthesis of purine. The resulting inhibition causes the bacteria to be unable to grow (bacteriostatic). This drug is administered as an oral tablet.

References

Sulfamethazine Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Hong YL, Hossler PA, Calhoun DH, Meshnick SR: Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. doi: 10.1128/AAC.39.8.1756.

Pubmed: 7486915

Friaza V, Morilla R, Respaldiza N, de la Horra C, Calderon EJ: Pneumocystis jiroveci dihydropteroate synthase gene mutations among colonized individuals and Pneumocystis pneumonia patients from Spain. Postgrad Med. 2010 Nov;122(6):24-8. doi: 10.3810/pgm.2010.11.2219.

Pubmed: 21084778

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Visualize Compound Data

		7,8-Dihydropterin pyrophosphate
		7,8-Dihydropteroic acid
		Adenosine diphosphate
		Adenosine triphosphate
		Dihydrofolic acid
		Hydrogen Ion
		L-Glutamic acid
		Magnesium
		NADP
		NADPH
		p-Aminobenzoic acid
		Phosphate
		Potassium
		Pyrophosphate
		Sulfamethazine
		Tetrahydrofolic acid