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Pathway Description
Sulfamethazine Action Pathway
Escherichia coli (strain K12)
Drug Action Pathway
Sulfamethazine is an antibacterial agent from the sulfanilamide drug class. It is used as a treatment for various bacterial infections, such as bronchitis, prostatitis, and urinary tract infections. Sulfamethazine inhibits the dihydropteroate synthetase enzyme. This protein does the condensation of pteridine and para-aminobenzoic acid (PABA) to produce tetrahydrofolic acid (THF). THF is required for the synthesis of purine. The resulting inhibition causes the bacteria to be unable to grow (bacteriostatic). This drug is administered as an oral tablet.
References
Sulfamethazine Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Hong YL, Hossler PA, Calhoun DH, Meshnick SR: Inhibition of recombinant Pneumocystis carinii dihydropteroate synthetase by sulfa drugs. Antimicrob Agents Chemother. 1995 Aug;39(8):1756-63. doi: 10.1128/AAC.39.8.1756.
Pubmed: 7486915
Friaza V, Morilla R, Respaldiza N, de la Horra C, Calderon EJ: Pneumocystis jiroveci dihydropteroate synthase gene mutations among colonized individuals and Pneumocystis pneumonia patients from Spain. Postgrad Med. 2010 Nov;122(6):24-8. doi: 10.3810/pgm.2010.11.2219.
Pubmed: 21084778
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