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Dihydropteroate synthase Sulfisoxazole transporter Sulfisoxazole transporter Sulfisoxazole transporter Acetyl sulfisoxazole transporter Bifunctional protein folC Dihydrofolate reductase Digestive enzyme Sulfisoxazole Tetrahydrofolic acid Sulfisoxazole Sulfisoxazole Sulfisoxazole Acetyl sulfisoxazole Acetyl sulfisoxazole Acetyl sulfisoxazole 7,8-Dihydropterin pyrophosphate p-Aminobenzoic acid 7,8-Dihydropteroic acid PPi ATP L-Glutamic acid Dihydrofolic acid ADP Pi NADPH H+ NADP Magnesium Potassium Magnesium Purine synthesis Tetrahydrofolate is needed for purine synthesis. Purines are needed to synthesis DNA and RNA. Lack of tetrahydrofolate prevents DNA and RNA synthesis leading to a bacteriostatic effect. Sulfisoxazole inhibits dihydropteroate synthase, preventing the production of tetrahydrofolate. Cytosol Urinary tract infection Blood Vessel Gram-Negative Bacteria Blood Vessel Intestine Cell
folP Unknown Unknown Unknown Unknown folC folA Unknown Sulfisoxazole Tetrahydrofolic acid Sulfisoxazole Sulfisoxazole Sulfisoxazole Acetyl sulfisoxazole Acetyl sulfisoxazole Acetyl sulfisoxazole 7,8- Dihydropterin pyrophosphate p-Aminobenzoic acid 7,8- Dihydropteroic acid Pyrophosphate Adenosine triphosphate L-Glutamic acid Dihydrofolic acid Adenosine diphosphate Phosphate NADPH Hydrogen Ion NADP Purine synthesis
folP folC folA Sulfafu THFA Sulfafu Sulfafu Sulfafu Ace sul Ace sul Ace sul 7,-Di p p-Amnba H2Pte PPi ATP Glu FAH2 ADP Pi NADPH H+ NADP Mg2+ K+ Mg2+ Pur syn Tetrahydrofolate is needed for purine synthesis. Purines are needed to synthesis DNA and RNA. Lack of tetrahydrofolate prevents DNA and RNA synthesis leading to a bacteriostatic effect. Sulfisoxazole inhibits dihydropteroate synthase, preventing the production of tetrahydrofolate. Cytosol Urinary tract infection Blood Vessel Gram-Negative Bacteria Blood Vessel Intestine Cell
folP folC folA Sulfafu THFA Sulfafu Sulfafu Sulfafu Ace sul Ace sul Ace sul 7,-Di p p-Amnba H2Pte Ppi ATP Glu FAH2 ADP Pi NADPH H+ NADP Pur syn