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Pathway Description
Sulfoxone Action Pathway
Mycobacterium leprae
Drug Action Pathway
Sulfoxone, also known as aldesulfone sodium, is a sulfonamide antibiotic with bacteriostatic activity. It is indicated in the treatment of leprosy and dermatitis herpetiformis. Leprosy is caused by Mycobacterium leprae. Sulfoxone inhibits the growth of the bacteria by inhibiting competitively the dihydropteroate synthase enzyme. This results in the inability to bind the substrate, para-aminobenzoic acid (PABA) resulting in the inability of the bacteria to do the synthesis of folic acid. Without folic acid, the bacteria can not grow because it can not produce DNA anymore. Right now this drug has been discontinued. It is administered as an oral tablet.
References
Sulfoxone Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Katz SI: "Sulfoxone (Diasone) sodium for dermatitis herpetiformis" by Cornbleet, December 1951. Commentary: Sulfoxone (Diasone) in the treatment of dermatitis herpetiformis. Arch Dermatol. 1982 Oct;118(10):805-12. doi: 10.1001/archderm.118.10.805.
Pubmed: 6753759
Takahashi T: [Mutations of drug target molecules in Pneumocystis jirovecii isolates and future investigations]. Nihon Ishinkin Gakkai Zasshi. 2009;50(2):67-73. doi: 10.3314/jjmm.50.067.
Pubmed: 19430180
Peters JH, Murray JF Jr, Gordon GR: The disposition of sulfoxone and solasulfone in leprosy patients. Lepr Rev. 1975 Sep;46(3):171-80. doi: 10.5935/0305-7518.19750018.
Pubmed: 171530
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