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Pathway Description
Protein C Action Pathway
Homo sapiens
Drug Action Pathway
Protein C is also known under brand names such as Balfaxar, Beriplex, Ceprotin, Kcentra and Octaplex used to treat purpura fulminans and or coumarin-induced skin necrosis. Protein C is an endogenous plasma protein, a zymogen that interacts with thrombomodulin in order to be converted to its active form. Activated Protein C acts as a serine protease that acts by inactivating coagulation factors V and VIII, decreasing clot formation. Due to its anticoagulant nature herbs and supplements with similar activity should be avoided such as garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
References
Protein C Pathway References
Esmon CT: The protein C pathway. Chest. 2003 Sep;124(3 Suppl):26S-32S. doi: 10.1378/chest.124.3_suppl.26s.
Pubmed: 12970121
Hepner M, Karlaftis V: Protein C. Methods Mol Biol. 2013;992:365-72. doi: 10.1007/978-1-62703-339-8_29.
Pubmed: 23546729
Bonig H, Kuci Z, Kuci S, Bakhtiar S, Basu O, Bug G, Dennis M, Greil J, Barta A, Kallay KM, Lang P, Lucchini G, Pol R, Schulz A, Sykora KW, Teichert von Luettichau I, Herter-Sprie G, Ashab Uddin M, Jenkin P, Alsultan A, Buechner J, Stein J, Kelemen A, Jarisch A, Soerensen J, Salzmann-Manrique E, Hutter M, Schafer R, Seifried E, Paneesha S, Novitzky-Basso I, Gefen A, Nevo N, Beutel G, Schlegel PG, Klingebiel T, Bader P: Children and Adults with Refractory Acute Graft-versus-Host Disease Respond to Treatment with the Mesenchymal Stromal Cell Preparation "MSC-FFM"-Outcome Report of 92 Patients. Cells. 2019 Dec 5;8(12):1577. doi: 10.3390/cells8121577.
Pubmed: 31817480
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