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Pathway Description
Afatinib Action Pathway
Homo sapiens
Drug Action Pathway
Afatinib is a tyrosine kinase inhibitor used as an antineoplastic agent for the treatment of advanced or metastatic non-small cell lung cancer (NSCLC) with non-resistant EGFR mutations or resistance to platinum-based chemotherapy. Afatinib binds the phosphorylation domain of the epidermal growth factor receptor. This inhibits the activation of this receptor, thus the cascading signaling pathways, through RAS, can't happen. As a result, this drug provokes the inhibition of cell (cancer) proliferation. Also, Afatinib inhibits the receptor tyrosine-protein kinase erbB-2 and erbB-4. Those receptors usually send a signal to the cell to survive (through the transcription of many proteins and with the help of P13K, AKT, and mTOR). The inhibition of those receptors results in the inhibition of the survival of the cell (death/apoptosis). This drug is administered as an oral tablet.
References
Afatinib Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Wind S, Schnell D, Ebner T, Freiwald M, Stopfer P: Clinical Pharmacokinetics and Pharmacodynamics of Afatinib. Clin Pharmacokinet. 2017 Mar;56(3):235-250. doi: 10.1007/s40262-016-0440-1.
Pubmed: 27470518
Stopfer P, Marzin K, Narjes H, Gansser D, Shahidi M, Uttereuther-Fischer M, Ebner T: Afatinib pharmacokinetics and metabolism after oral administration to healthy male volunteers. Cancer Chemother Pharmacol. 2012 Apr;69(4):1051-61. doi: 10.1007/s00280-011-1803-9. Epub 2011 Dec 27.
Pubmed: 22200729
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