PathWhiz

Pathway Description

Pixantrone Action Pathway

Helicobacter pylori

Drug Action Pathway

Pixantrone is anaza-anthracenedione and DNA intercalator which inhibits topoisomerase II, used to treat patients with relapsed or refractory aggressive Non-Hodgkin B-cell Lymphomas Pixantrone inhibits DNA gyrase (topoisomerase II). DNA gyrase prevents supercoiling in bacterial DNA. The inhibition of DNA gyrase (topoisomerase II) and topoisomerase IV causes supercoiling of the bacterial DNA. This prevents DNA replication.

References

Pixantrone Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Evison BJ, Mansour OC, Menta E, Phillips DR, Cutts SM: Pixantrone can be activated by formaldehyde to generate a potent DNA adduct forming agent. Nucleic Acids Res. 2007;35(11):3581-9. doi: 10.1093/nar/gkm285. Epub 2007 May 5.

Pubmed: 17483512

Jamal-Hanjani M, Pettengell R: Pharmacokinetic evaluation of pixantrone for the treatment of non-Hodgkin's lymphoma. Expert Opin Drug Metab Toxicol. 2011 Nov;7(11):1441-8. doi: 10.1517/17425255.2011.618834. Epub 2011 Sep 12.

Pubmed: 21905966

Highlighted elements will appear in red.

Highlight Compounds

	Magnesium
	Pixantrone

Highlight Proteins

	DNA gyrase subunit A
	DNA gyrase subunit B

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