PathWhiz

Pathway Description

Adapalene Predicted Metabolism

Homo sapiens

Metabolic Pathway

Adapalene is a third-generation topical retinoid with anti-comedogenic, comedolytic, and anti-inflammatory properties used to treat acne vulgaris in adolescents and adults. Extensive information regarding adapalene metabolism in humans is unavailable, although it is known to accumulate in the liver and GI-tract. In human, mouse, rat, rabbit, and dog cultured hepatocytes, metabolism appears to affect the methoxybenzene moiety but remains incompletely characterized. The major products of metabolism are glucuronides. Approximately 25% of the drug is metabolized; the rest is excreted as parent drug. Adapalene PIS1M1 is a metabolite of Adapalene predicted with biotransformer.

References

Adapalene Predicted Metabolism References

Wishart DS, Tian S, Allen D, Oler E, Peters H, Lui VW, Gautam V, Djoumbou-Feunang Y, Greiner R, Metz TO: BioTransformer 3.0-a web server for accurately predicting metabolic transformation products. Nucleic Acids Res. 2022 Jul 5;50(W1):W115-W123. doi: 10.1093/nar/gkac313.

Pubmed: 35536252

Highlighted elements will appear in red.

Highlight Compounds

	Adapalene
	Adapalene PIS1M1
	Heme

Highlight Proteins

Cytochrome P450 1A2

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