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Solute carrier family 22 member 2 Cytochrome P450 2C9 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 1A2 Cytochrome P450 3A4 Cytochrome P450 2C9 Cytochrome P450 2D6 Sildenafil Sildenafil Sildenafil PIS2M1 Sildenafil PIS2M1 Sildenafil PIS1M1 Sildenafil PIS1M1 Sildenafil PIS1M2 Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel
Endoplasmic Reticulum Endoplasmic Reticulum SLC22A2 CYP2C9 CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP2C9 CYP2D6 Sildenafil Sildenafil Sildenafil PIS2M1 Sildenafil PIS2M1 Sildenafil PIS1M1 Sildenafil PIS1M1 Sildenafil PIS1M2 Urinary Excretion and/or Bile duct Excretion
SLC22A2 CYP2C9 CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP2C9 CYP2D6 Viagra Viagra Sil PIS Sil PIS Sil PIS Sil PIS Sil PIS Heme Heme Heme Heme Heme Heme U E a B Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel
Endoplasmic Reticulum Endoplasmic Reticulum SLC22A2 CYP2C9 CYP3A4 CYP3A4 CYP1A2 CYP3A4 CYP2C9 CYP2D6 Viagra Viagra Sil PIS Sil PIS Sil PIS Sil PIS Sil PIS U E a B