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ATP-binding cassette sub-family A member 1 Cytochrome P450 1A2 Cytochrome P450 3A4 Sildenafil PIS2M1 Sildenafil PIS2M1 Ticlopidine Ticlopidine Ticlopidine PIS1M1 Ticlopidine PIS1M2 Ticlopidine PIS1M3 Ticlopidine PIS1M4 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel
Endoplasmic Reticulum Endoplasmic Reticulum ABCA1 CYP1A2 CYP3A4 Sildenafil PIS2M1 Sildenafil PIS2M1 Ticlopidine Ticlopidine Ticlopidine PIS1M1 Ticlopidine PIS1M2 Ticlopidine PIS1M3 Ticlopidine PIS1M4 Urinary Excretion and/or Bile duct Excretion
ABCA1 CYP1A2 CYP3A4 Sil PIS Sil PIS Ticlopi Ticlopi Tic PIS Tic PIS Tic PIS Tic PIS Heme Heme U E a B Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel
Endoplasmic Reticulum Endoplasmic Reticulum ABCA1 CYP1A2 CYP3A4 Sil PIS Sil PIS Ticlopi Ticlopi Tic PIS Tic PIS Tic PIS Tic PIS U E a B