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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 2B6 Cytochrome P450 2C19 Cytochrome P450 2C8 Cytochrome P450 3A4 Cytochrome P450 2D6 Cytochrome P450 2C8 Cytochrome P450 3A4 Cytochrome P450 2C9 Pentazocine Pentazocine PIS2M1 Pentazocine PIS2M1 Pentazocine PIS2M3 Pentazocine PIS2M3 Pentazocine PIS2M2 Pentazocine PIS2M2 Pentazocine PIS2M3 Pentazocine PIS2M3 Pentazocine Pentazocine PIS1M1 Pentazocine PIS1M2 Pentazocine PIS1M3 Pentazocine PIS1M4 Heme Heme Heme Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Kidney Bile Ducts Liver Blood Vessel Blood Vessel Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP2B6 CYP2C19 CYP2C8 CYP3A4 CYP2D6 CYP2C8 CYP3A4 CYP2C9 Pentazocine Pentazocine PIS2M1 Pentazocine PIS2M1 Pentazocine PIS2M3 Pentazocine PIS2M3 Pentazocine PIS2M2 Pentazocine PIS2M2 Pentazocine PIS2M3 Pentazocine PIS2M3 Pentazocine Pentazocine PIS1M1 Pentazocine PIS1M2 Pentazocine PIS1M3 Pentazocine PIS1M4 Urinary Excretion and/or Bile duct Excretion