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Cytochrome P450 1A2 Adapalene Adapalene Adapalene PIS1M1 Adapalene PIS1M1 Heme Urinary Excretion and/or Bile duct Excretion Hepatocytes Kidney Liver Cytosol Adapalene undergoes metabolism to give Adapalene PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP1A2 Adapalene Adapalene Adapalene PIS1M1 Adapalene PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP1A2 Adaferi Adaferi Ada PIS Ada PIS Heme U E a B Hepatocytes Kidney Liver Cytosol Adapalene undergoes metabolism to give Adapalene PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP1A2 Adaferi Adaferi Ada PIS Ada PIS U E a B