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Cytochrome P450 3A4 Acitretin Acitretin Acitretin PIS1M1 Acitretin PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Acitretin undergoes metabolism to give Acitretin PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Acitretin Acitretin Acitretin PIS1M1 Acitretin PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Etretin Etretin Aci PIS Aci PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Acitretin undergoes metabolism to give Acitretin PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Etretin Etretin Aci PIS Aci PIS U E a B