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Cytochrome P450 3A4 Cabozantinib Cabozantinib Cabozantinib PIS1M1 Cabozantinib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Cabozantinib undergoes metabolism to give Cabozantinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Cabozantinib Cabozantinib Cabozantinib PIS1M1 Cabozantinib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Caboz Caboz Cab PIS Cab PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Cabozantinib undergoes metabolism to give Cabozantinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Caboz Caboz Cab PIS Cab PIS U E a B