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Cytochrome P450 3A4 Lorlatinib Lorlatinib Lorlatinib PIS1M1 Lorlatinib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Lorlatinib undergoes metabolism to give Lorlatinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Lorlatinib Lorlatinib Lorlatinib PIS1M1 Lorlatinib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Lorla Lorla Lor PIS Lor PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Lorlatinib undergoes metabolism to give Lorlatinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Lorla Lorla Lor PIS Lor PIS U E a B