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Cytochrome P450 3A4 Paclitaxel Paclitaxel Paclitaxel PIS1M1 Paclitaxel PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Paclitaxel undergoes metabolism to give Paclitaxel PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Paclitaxel Paclitaxel Paclitaxel PIS1M1 Paclitaxel PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Paclxl Paclxl Pac PIS Pac PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Paclitaxel undergoes metabolism to give Paclitaxel PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Paclxl Paclxl Pac PIS Pac PIS U E a B