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Cytochrome P450 3A4 Pimozide Pimozide Pimozide PIS1M1 Pimozide PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Pimozide undergoes metabolism to give Pimozide PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Pimozide Pimozide Pimozide PIS1M1 Pimozide PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Orap Orap Pim PIS Pim PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Pimozide undergoes metabolism to give Pimozide PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Orap Orap Pim PIS Pim PIS U E a B