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Cytochrome P450 3A4 Pralsetinib Pralsetinib Pralsetinib PIS1M1 Pralsetinib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Pralsetinib undergoes metabolism to give Pralsetinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Pralsetinib Pralsetinib Pralsetinib PIS1M1 Pralsetinib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Prals Prals Pra PIS Pra PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Pralsetinib undergoes metabolism to give Pralsetinib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Prals Prals Pra PIS Pra PIS U E a B