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Cytochrome P450 3A4 Probenecid Probenecid Probenecid PIS1M1 Probenecid PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Probenecid undergoes metabolism to give Probenecid PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Probenecid Probenecid Probenecid PIS1M1 Probenecid PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Probene Probene Pro PIS Pro PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Probenecid undergoes metabolism to give Probenecid PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Probene Probene Pro PIS Pro PIS U E a B