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Cytochrome P450 3A4 Rifamycin Rifamycin Rifamycin PIS1M1 Rifamycin PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Rifamycin undergoes metabolism to give Rifamycin PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Rifamycin Rifamycin Rifamycin PIS1M1 Rifamycin PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Rifam Rifam Rif PIS Rif PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Rifamycin undergoes metabolism to give Rifamycin PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Rifam Rifam Rif PIS Rif PIS U E a B