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Cytochrome P450 3A4 Rifaximin Rifaximin Rifaximin PIS1M1 Rifaximin PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Rifaximin undergoes metabolism to give Rifaximin PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Rifaximin Rifaximin Rifaximin PIS1M1 Rifaximin PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Xifaxsa Xifaxsa Rif PIS Rif PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Rifaximin undergoes metabolism to give Rifaximin PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Xifaxsa Xifaxsa Rif PIS Rif PIS U E a B