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Cytochrome P450 3A4 Telaprevir Telaprevir Telaprevir PIS1M1 Telaprevir PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Telaprevir undergoes metabolism to give Telaprevir PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Telaprevir Telaprevir Telaprevir PIS1M1 Telaprevir PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 VX-950 VX-950 Tel PIS Tel PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Telaprevir undergoes metabolism to give Telaprevir PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 VX-950 VX-950 Tel PIS Tel PIS U E a B