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Cytochrome P450 3A4 Tezacaftor Tezacaftor Tezacaftor PIS1M1 Tezacaftor PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Tezacaftor undergoes metabolism to give Tezacaftor PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tezacaftor Tezacaftor Tezacaftor PIS1M1 Tezacaftor PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Tezac Tezac Tez PIS Tez PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Tezacaftor undergoes metabolism to give Tezacaftor PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tezac Tezac Tez PIS Tez PIS U E a B