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Cytochrome P450 3A4 Tipranavir Tipranavir Tipranavir PIS1M1 Tipranavir PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Tipranavir undergoes metabolism to give Tipranavir PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tipranavir Tipranavir Tipranavir PIS1M1 Tipranavir PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Tpv Tpv Tip PIS Tip PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Tipranavir undergoes metabolism to give Tipranavir PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tpv Tpv Tip PIS Tip PIS U E a B