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Cytochrome P450 3A4 Tolvaptan Tolvaptan Tolvaptan PIS1M1 Tolvaptan PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Tolvaptan undergoes metabolism to give Tolvaptan PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tolvaptan Tolvaptan Tolvaptan PIS1M1 Tolvaptan PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Tolva Tolva Tol PIS Tol PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Tolvaptan undergoes metabolism to give Tolvaptan PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tolva Tolva Tol PIS Tol PIS U E a B