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Cytochrome P450 3A4 Topiramate Topiramate Topiramate PIS1M1 Topiramate PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Topiramate undergoes metabolism to give Topiramate PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Topiramate Topiramate Topiramate PIS1M1 Topiramate PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Tpm Tpm Top PIS Top PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Topiramate undergoes metabolism to give Topiramate PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Tpm Tpm Top PIS Top PIS U E a B