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Cytochrome P450 3A4 Umbralisib Umbralisib Umbralisib PIS1M1 Umbralisib PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Umbralisib undergoes metabolism to give Umbralisib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Umbralisib Umbralisib Umbralisib PIS1M1 Umbralisib PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 Umbra Umbra Umb PIS Umb PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Umbralisib undergoes metabolism to give Umbralisib PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Umbra Umbra Umb PIS Umb PIS U E a B