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Cytochrome P450 1A2 Sitaxentan Sitaxentan Sitaxentan PIS1M1 Sitaxentan PIS1M1 Heme Urinary Excretion and/or Bile duct Excretion Hepatocytes Kidney Liver Cytosol Sitaxentan undergoes metabolism to give Sitaxentan PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP1A2 Sitaxentan Sitaxentan Sitaxentan PIS1M1 Sitaxentan PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP1A2 Tbc Tbc Sit PIS Sit PIS Heme U E a B Hepatocytes Kidney Liver Cytosol Sitaxentan undergoes metabolism to give Sitaxentan PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP1A2 Tbc Tbc Sit PIS Sit PIS U E a B