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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Benzthiazide PIS2M1 Benzthiazide Benzthiazide Benzthiazide PIS1M1 Benzthiazide PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Benzthiazide undergoes metabolism to give Benzthiazide PIS1M1 and Benzthiazide PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Benzthiazide PIS2M1 Benzthiazide Benzthiazide Benzthiazide PIS1M1 Benzthiazide PIS2M1 Urinary Excretion and/or Bile duct Excretion