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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Olaparib PIS2M1 Olaparib Olaparib Olaparib PIS1M1 Olaparib PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Olaparib undergoes metabolism to give Olaparib PIS1M1 and Olaparib PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Olaparib PIS2M1 Olaparib Olaparib Olaparib PIS1M1 Olaparib PIS2M1 Urinary Excretion and/or Bile duct Excretion