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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Sibutramine PIS2M1 Sibutramine Sibutramine Sibutramine PIS1M1 Sibutramine PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Sibutramine undergoes metabolism to give Sibutramine PIS1M1 and Sibutramine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Sibutramine PIS2M1 Sibutramine Sibutramine Sibutramine PIS1M1 Sibutramine PIS2M1 Urinary Excretion and/or Bile duct Excretion