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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Teniposide PIS2M1 Teniposide Teniposide Teniposide PIS1M1 Teniposide PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Teniposide undergoes metabolism to give Teniposide PIS1M1 and Teniposide PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Teniposide PIS2M1 Teniposide Teniposide Teniposide PIS1M1 Teniposide PIS2M1 Urinary Excretion and/or Bile duct Excretion