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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Tolcapone PIS2M1 Tolcapone Tolcapone Tolcapone PIS1M1 Tolcapone PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Tolcapone undergoes metabolism to give Tolcapone PIS1M1 and Tolcapone PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Tolcapone PIS2M1 Tolcapone Tolcapone Tolcapone PIS1M1 Tolcapone PIS2M1 Urinary Excretion and/or Bile duct Excretion