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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Topotecan PIS2M1 Topotecan Topotecan Topotecan PIS1M1 Topotecan PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Topotecan undergoes metabolism to give Topotecan PIS1M1 and Topotecan PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Topotecan PIS2M1 Topotecan Topotecan Topotecan PIS1M1 Topotecan PIS2M1 Urinary Excretion and/or Bile duct Excretion