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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Valdecoxib PIS2M1 Valdecoxib Valdecoxib Valdecoxib PIS1M1 Valdecoxib PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Valdecoxib undergoes metabolism to give Valdecoxib PIS1M1 and Valdecoxib PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Valdecoxib PIS2M1 Valdecoxib Valdecoxib Valdecoxib PIS1M1 Valdecoxib PIS2M1 Urinary Excretion and/or Bile duct Excretion