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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Ioflupane I-123 PIS1M1 Ioflupane I-123 PIS1M2 Ioflupane I-123 Ioflupane I-123 Ioflupane I-123 PIS1M1 Ioflupane I-123 PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Ioflupane I-123 undergoes metabolism to give Ioflupane I-123 PIS1M1 and Ioflupane I-123 PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Ioflupane I-123 PIS1M1 Ioflupane I-123 PIS1M2 Ioflupane I-123 Ioflupane I-123 Ioflupane I-123 PIS1M1 Ioflupane I-123 PIS1M2 Urinary Excretion and/or Bile duct Excretion