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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Mebrofenin PIS1M1 Mebrofenin PIS1M2 Mebrofenin Mebrofenin Mebrofenin PIS1M1 Mebrofenin PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Mebrofenin undergoes metabolism to give Mebrofenin PIS1M1 and Mebrofenin PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Mebrofenin PIS1M1 Mebrofenin PIS1M2 Mebrofenin Mebrofenin Mebrofenin PIS1M1 Mebrofenin PIS1M2 Urinary Excretion and/or Bile duct Excretion