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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Palonosetron PIS1M1 Palonosetron PIS1M2 Palonosetron Palonosetron Palonosetron PIS1M1 Palonosetron PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Palonosetron undergoes metabolism to give Palonosetron PIS1M1 and Palonosetron PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Palonosetron PIS1M1 Palonosetron PIS1M2 Palonosetron Palonosetron Palonosetron PIS1M1 Palonosetron PIS1M2 Urinary Excretion and/or Bile duct Excretion