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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Pramipexole PIS1M1 Pramipexole PIS1M2 Pramipexole Pramipexole Pramipexole PIS1M1 Pramipexole PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Pramipexole undergoes metabolism to give Pramipexole PIS1M1 and Pramipexole PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Pramipexole PIS1M1 Pramipexole PIS1M2 Pramipexole Pramipexole Pramipexole PIS1M1 Pramipexole PIS1M2 Urinary Excretion and/or Bile duct Excretion