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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Remifentanil PIS1M1 Remifentanil PIS1M2 Remifentanil Remifentanil Remifentanil PIS1M1 Remifentanil PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Remifentanil undergoes metabolism to give Remifentanil PIS1M1 and Remifentanil PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Remifentanil PIS1M1 Remifentanil PIS1M2 Remifentanil Remifentanil Remifentanil PIS1M1 Remifentanil PIS1M2 Urinary Excretion and/or Bile duct Excretion