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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Riluzole PIS1M1 Riluzole PIS1M2 Riluzole Riluzole Riluzole PIS1M1 Riluzole PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Riluzole undergoes metabolism to give Riluzole PIS1M1 and Riluzole PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Riluzole PIS1M1 Riluzole PIS1M2 Riluzole Riluzole Riluzole PIS1M1 Riluzole PIS1M2 Urinary Excretion and/or Bile duct Excretion