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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Yohimbine PIS1M1 Yohimbine PIS1M2 Yohimbine Yohimbine Yohimbine PIS1M1 Yohimbine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Yohimbine undergoes metabolism to give Yohimbine PIS1M1 and Yohimbine PIS1M2.
Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 Yohimbine PIS1M1 Yohimbine PIS1M2 Yohimbine Yohimbine Yohimbine PIS1M1 Yohimbine PIS1M2 Urinary Excretion and/or Bile duct Excretion