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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Pentazocine Pentazocine PIS4M1 Pentazocine PIS4M1 Pentazocine Pentazocine PIS1M1 Pentazocine PIS2M1 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Kidney Bile Ducts Liver Blood Vessel Blood Vessel Many other Cytochrome P450 enzymes are involved in Phase I (PI) Step 1(S1) and Step 2(S2) reactions. Sildenafil undergoes metabolism to give Sildenafil PIS1M1, Sildenafil PIS2M1 and Sildenafil PIS4M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 CYP3A4 Pentazocine Pentazocine PIS4M1 Pentazocine PIS4M1 Pentazocine Pentazocine PIS1M1 Pentazocine PIS2M1 Urinary Excretion and/or Bile duct Excretion