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Unknown Cytochrome P450 2D6 Cytochrome P450 3A4 Cytochrome P450 1A2 Sildenafil PIS2M1 Sildenafil PIS2M1 Sildenafil PIS1M1 Sildenafil PIS1M1 Sildenafil Sildenafil Sildenafil PIS1M2 Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Sildenafil undergoes metabolism to give Sildenafil PIS1M1, Sildenafil PIS1M2 and Sildenafil PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP2D6 CYP3A4 CYP1A2 Sildenafil PIS2M1 Sildenafil PIS2M1 Sildenafil PIS1M1 Sildenafil PIS1M1 Sildenafil Sildenafil Sildenafil PIS1M2 Urinary Excretion and/or Bile duct Excretion