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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Acrivastine PIS2M1 Acrivastine PIS2M1 Acrivastine PIS1M1 Acrivastine PIS1M1 Acrivastine Acrivastine Acrivastine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Acrivastine undergoes metabolism to give Acrivastine PIS1M1, Acrivastine PIS1M2 and Acrivastine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Acrivastine PIS2M1 Acrivastine PIS2M1 Acrivastine PIS1M1 Acrivastine PIS1M1 Acrivastine Acrivastine Acrivastine PIS1M2 Urinary Excretion and/or Bile duct Excretion