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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Berberine PIS2M1 Berberine PIS2M1 Berberine PIS1M1 Berberine PIS1M1 Berberine Berberine Berberine PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Berberine undergoes metabolism to give Berberine PIS1M1, Berberine PIS1M2 and Berberine PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Berberine PIS2M1 Berberine PIS2M1 Berberine PIS1M1 Berberine PIS1M1 Berberine Berberine Berberine PIS1M2 Urinary Excretion and/or Bile duct Excretion